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Chemical Engineering News

Found a molecular mechanism involved in the development of autoimmune diseases

Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) and the University of Las Palmas de Gran Canaria and California (USA) have discovered a molecular mechanism involved in the development of autoimmune diseases like lupus. These are the receptors LXR (Liver X Receptors) that regulate the removal of the remains of dead cells by apoptosis, a process that, when it fails, it causes inflammation of surrounding tissue and the body's immune response. The research, conducted with mice, opens the door to the use of these receptors as therapeutic targets for these diseases.

Antonio Castrillo, CSIC researcher at the Institute for Biomedical Research (Joint CSIC and Universidad Autónoma de Madrid) and director of research, explains: "The research in mice has shown that in the absence of these receptors, the process of removal of dead cells is severely compromised. "According to the research, these receptors, proteins residing in the cell nucleus and known so far for its role in cholesterol metabolism, regulate the expression of an important gene involved in removal of cellular debris.


Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) and the University of Las Palmas de Gran Canaria and California (USA) have discovered a molecular mechanism involved in the development of autoimmune diseases like lupus. These are the receptors LXR (Liver X Receptors) that regulate the removal of the remains of dead cells by apoptosis, a process that, when it fails, it causes inflammation of surrounding tissue and the body's immune response. The research, conducted with mice, opens the door to the use of these receptors as therapeutic targets for these diseases.

Antonio Castrillo, CSIC researcher at the Institute for Biomedical Research (Joint CSIC and Universidad Autónoma de Madrid) and director of research, explains: "The research in mice has shown that in the absence of these receptors, the process of removal of dead cells is severely compromised. "According to the research, these receptors, proteins residing in the cell nucleus and known so far for its role in cholesterol metabolism, regulate the expression of an important gene involved in removal of cellular debris.

Braskem and Acinplas establish an agreement

Braskem and Acinplas just a close partnership for the provision of green polyethylene from 100% renewable origin. The resin is used in the manufacture of plastic films, which will be transformed into a licensed product under the name Unisold System ®, used by companies run by Acinplas - Suzuki, Koba, Plasa, and Tashiro Voti & Takata. This system helps the consumer in the purchase of fruit and vegetable sector frutihortícola of the major supermarkets in Brazil and Europe, providing perforated bags to put up with convenience foods, health and strength.

The partnership was made possible thanks to the goal of sustainable business practices, particularly with regard to the environment because the consumer market increasingly demands products produced by environmentally correct and socially and environmentally responsible.


Braskem and Acinplas just a close partnership for the provision of green polyethylene from 100% renewable origin. The resin is used in the manufacture of plastic films, which will be transformed into a licensed product under the name Unisold System ®, used by companies run by Acinplas - Suzuki, Koba, Plasa, and Tashiro Voti & Takata. This system helps the consumer in the purchase of fruit and vegetable sector frutihortícola of the major supermarkets in Brazil and Europe, providing perforated bags to put up with convenience foods, health and strength.

The partnership was made possible thanks to the goal of sustainable business practices, particularly with regard to the environment because the consumer market increasingly demands products produced by environmentally correct and socially and environmentally responsible.

Human and bacterial proteins are similar concerning the organization of DNA and gene expression

A study by researchers from the Consejo Superior de Investigaciones Científicas (CSIC) and Universidad de Murcia has found that some bacterial proteins are very similar to human proteins. Specifically, the research details the similarities between HMGA and histone H1, human protein Card and two bacteria. All of them perform functions related to
the formation of DNA and gene expression. The research is published in PNAS.


A study by researchers from the Consejo Superior de Investigaciones Científicas (CSIC) and Universidad de Murcia has found that some bacterial proteins are very similar to human proteins. Specifically, the research details the similarities between HMGA and histone H1, human protein Card and two bacteria. All of them perform functions related to
the formation of DNA and gene expression. The research is published in PNAS.

CSIC researchers have reproduced in the laboratory machinery multiplication of influenza virus

Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) have recreated in the laboratory that uses the molecular machinery of the influenza virus to replicate and express its genetic material, one of the key aspects of their life cycle and, Consequently, the success of their infection. The work provides a new tool for scientists to conduct structural studies and to better understand the processes of gene expression and replication of the virus.

The research, published in PLoS Pathogens, has been led by researchers at the CSIC Juan Ortín and Jaime Martín-Benito, National Center for Biotechnology (CSIC) in Madrid. The authors have used biochemical techniques to create this reproduction, which can observe the machinery of virus replication with electron microscopy and, in turn, deepen the understanding of the virus. So far, the replication machinery could not be observed by electron microscopy because of its flexibility.


Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) have recreated in the laboratory that uses the molecular machinery of the influenza virus to replicate and express its genetic material, one of the key aspects of their life cycle and, Consequently, the success of their infection. The work provides a new tool for scientists to conduct structural studies and to better understand the processes of gene expression and replication of the virus.

The research, published in PLoS Pathogens, has been led by researchers at the CSIC Juan Ortín and Jaime Martín-Benito, National Center for Biotechnology (CSIC) in Madrid. The authors have used biochemical techniques to create this reproduction, which can observe the machinery of virus replication with electron microscopy and, in turn, deepen the understanding of the virus. So far, the replication machinery could not be observed by electron microscopy because of its flexibility.

Afton Chemical conducts strategic investment in a plant in Asia Pacific

Afton Chemical Corporation announces new investment in plant Asia Pacific to provide better service to our clients in the region. This new plant will improve the supply security and reduce delivery times to specific-use products using cutting edge technology.

Warren Huang, president, said: "Afton is investing in the Asia Pacific region to generate power and produce specific solutions within the region"


Afton Chemical Corporation announces new investment in plant Asia Pacific to provide better service to our clients in the region. This new plant will improve the supply security and reduce delivery times to specific-use products using cutting edge technology.

Warren Huang, president, said: "Afton is investing in the Asia Pacific region to generate power and produce specific solutions within the region"

Discover a new way to control the movement of objects at the nanoscale

Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) has discovered a new way to control up to a limit unprecedented movements of objects at the nanoscale. The investigation, which is published in the latest issue of Science, offers new opportunities for development and improvement of many nanotechnology applications such as nanosensors to detect masses so small that the nucleus of an atom.

The research was led by Adrian Bachtold researcher, group leader of the Quantum Nanoelectronics Research Center for Nanoscience and Nanotechnology CIN2 (CSIC Joint and ICN), in Bellaterra, Barcelona. Bachtold and his colleague, Daniel Garcia Sanchez and Benjamin Lassagne have enjoyed the cooperation of Yury Tarakanov and Jari Kinarett, scientists at the Chalmers University of Technology, Gothenburg (Sweden).


Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) has discovered a new way to control up to a limit unprecedented movements of objects at the nanoscale. The investigation, which is published in the latest issue of Science, offers new opportunities for development and improvement of many nanotechnology applications such as nanosensors to detect masses so small that the nucleus of an atom.

The research was led by Adrian Bachtold researcher, group leader of the Quantum Nanoelectronics Research Center for Nanoscience and Nanotechnology CIN2 (CSIC Joint and ICN), in Bellaterra, Barcelona. Bachtold and his colleague, Daniel Garcia Sanchez and Benjamin Lassagne have enjoyed the cooperation of Yury Tarakanov and Jari Kinarett, scientists at the Chalmers University of Technology, Gothenburg (Sweden).

Research on genes for multiple drug resistance in cancer

Cellectricon has announced its collaboration with the University of Lodz (Poland). Under the agreement, the University of Lodz will invest in Cellaxess (R) HT, the world's first system for high transfection efficiency that allow delivery of reagents free of any genetic material to cells.

"We are excited in relation to collaboration with Cellectricon, and we believe that the system Cellaxess (R) HT will be a big step forward for our efforts within our research program focused on cell biology and molecular genetics of genes associated with clinically relevant treatment cancer, "said Bartosz profesorGrzegorz, head of the department of molecular biophysics at the University of Lodz. The genomic control is a rapidly evolving field, and the need is very important around the technology that allows a high transfection efficiency and viability in most cell types. Cellaxess (R) HT will allow us to take an ambitious expression and mute control processes that would otherwise have been viable in the economic aspect in the study with conventional instrumentation. The acquisition system Cellaxess (R) HT by the University of Lodz was made possible by funds from the Operational Program Innovative Economy Republic of Poland, which have been supported in part by the European Union through the Fund European Regional Development.


Cellectricon has announced its collaboration with the University of Lodz (Poland). Under the agreement, the University of Lodz will invest in Cellaxess (R) HT, the world's first system for high transfection efficiency that allow delivery of reagents free of any genetic material to cells.

"We are excited in relation to collaboration with Cellectricon, and we believe that the system Cellaxess (R) HT will be a big step forward for our efforts within our research program focused on cell biology and molecular genetics of genes associated with clinically relevant treatment cancer, "said Bartosz profesorGrzegorz, head of the department of molecular biophysics at the University of Lodz. The genomic control is a rapidly evolving field, and the need is very important around the technology that allows a high transfection efficiency and viability in most cell types. Cellaxess (R) HT will allow us to take an ambitious expression and mute control processes that would otherwise have been viable in the economic aspect in the study with conventional instrumentation. The acquisition system Cellaxess (R) HT by the University of Lodz was made possible by funds from the Operational Program Innovative Economy Republic of Poland, which have been supported in part by the European Union through the Fund European Regional Development.

CSIC's work shows that the activity of a type of protein is essential for the regeneration of neural stem cells

A team from the Consejo Superior de Investigaciones Científicas (CSIC) has shown that the activity of the Polycomb protein is essential for proper differentiation of self and neural stem cells. According to managers of work, researchers at the CSIC and Carlos Miguel Vidal Vicario, control of these processes is "important" for the use of stem cells and differentiated cells in cell therapy protocols and regenerative medicine.

At work, he has published in its July issue the journal Stem Cells, have been used genetically modified mice to investigate the activity of Polycomb group genes, one of the epigenetic regulation modules (the mechanisms of genetic regulation that do not involve changes in DNA sequences), the self of the neural stem cells. Specifically, researchers conducted conditional inactivation of the protein RING1B.


A team from the Consejo Superior de Investigaciones Científicas (CSIC) has shown that the activity of the Polycomb protein is essential for proper differentiation of self and neural stem cells. According to managers of work, researchers at the CSIC and Carlos Miguel Vidal Vicario, control of these processes is "important" for the use of stem cells and differentiated cells in cell therapy protocols and regenerative medicine.

At work, he has published in its July issue the journal Stem Cells, have been used genetically modified mice to investigate the activity of Polycomb group genes, one of the epigenetic regulation modules (the mechanisms of genetic regulation that do not involve changes in DNA sequences), the self of the neural stem cells. Specifically, researchers conducted conditional inactivation of the protein RING1B.

A study involving the CSIC get a molecule that could serve to regenerate neurons

A study involving the Consejo Superior de Investigaciones Científicas (CSIC) gets a molecule that could serve to regenerate neurons. The work, led by the Institute of Biomedical Research of Barcelona, has achieved a compound that in vitro growing axons of injured neurons in mice. This substance could be used in future to design new drugs that promote axonal regeneration in spinal cord injuries. The work has also engaged the University of Barcelona.

Axons, extensions of nerve cells through which nerve impulses travel, allowing the connection of neuron to neuron and the execution of orders from the brain to the muscles. One of the main problems of the nervous system of an adult is the inability of regenerating axons when they suffer an injury.


A study involving the Consejo Superior de Investigaciones Científicas (CSIC) gets a molecule that could serve to regenerate neurons. The work, led by the Institute of Biomedical Research of Barcelona, has achieved a compound that in vitro growing axons of injured neurons in mice. This substance could be used in future to design new drugs that promote axonal regeneration in spinal cord injuries. The work has also engaged the University of Barcelona.

Axons, extensions of nerve cells through which nerve impulses travel, allowing the connection of neuron to neuron and the execution of orders from the brain to the muscles. One of the main problems of the nervous system of an adult is the inability of regenerating axons when they suffer an injury.

CSIC's researchers estimate that the 'Neanderthal Eve "lived around 110,000 years ago

Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) in collaboration with the German Max Planck Institute and the University of Oviedo have recovered the entire mitochondrial DNA genome of Neanderthals five. Among other findings, scientists estimate that the last common mother of all Neanderthals mitochondrial genomes, the so-called 'mitochondrial Eve' Neanderthal who lived 110,000 years ago, it would be more recent than that of modern humans, the researchers found in Africa makes 150,000.

The mitochondrial genome is the DNA that is inside the mitochondria, which has the particularity to be transmitted only by maternal line. Their analysis allows to determine the common ancestor of a species, the so-called 'mitochondrial Eve'. In this case, the analysis of the five genomes have revealed that the 'mitochondrial Eve' Neanderthal lived only 110,000 years ago. CSIC researcher Antonio Rosas, co-author of the article, says: "This date is newer than the one obtained with previous models based on the fossil record."


Investigators from the Consejo Superior de Investigaciones Científicas (CSIC) in collaboration with the German Max Planck Institute and the University of Oviedo have recovered the entire mitochondrial DNA genome of Neanderthals five. Among other findings, scientists estimate that the last common mother of all Neanderthals mitochondrial genomes, the so-called 'mitochondrial Eve' Neanderthal who lived 110,000 years ago, it would be more recent than that of modern humans, the researchers found in Africa makes 150,000.

The mitochondrial genome is the DNA that is inside the mitochondria, which has the particularity to be transmitted only by maternal line. Their analysis allows to determine the common ancestor of a species, the so-called 'mitochondrial Eve'. In this case, the analysis of the five genomes have revealed that the 'mitochondrial Eve' Neanderthal lived only 110,000 years ago. CSIC researcher Antonio Rosas, co-author of the article, says: "This date is newer than the one obtained with previous models based on the fossil record."

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