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Researchers at the University of Zaragoza and Consejo Superior de Investigaciones Científicas (CSIC) have made new findings from the project ROSAS, dedicated to the study of free radicals - responsible, among other things, the aging celulary by extension-related diseases, such as hypertension, fibrosis, mitochondrial disease (included within the so-called rare diseases) or Alzheimer's. Research has been published in the journal Proceedings of the National Academy of
Science, Molecular and Cellular Biology and Molecular Cell.

Among other achievements, researchers have identified a biomarker that could serve as early warning of oxidative stress caused by free radicals and hence the risk of developing diseases such as hypertension or fibrosis. Specifically, scientists at the Centro de Investigaciones Biológicas CSIC in Madrid have identified a cellular enzyme, the GAPDH (glyceraldehyde 3-phosphate dehydrogenase), which in normal conditions, interacts with certain structural elements of the messenger RNA, resulting in a low production of endothelin -1, a peptide involved in regulating vascular tone and related diseases such as hypertension or fibrosis.

Researchers at the University of Zaragoza and Consejo Superior de Investigaciones Científicas (CSIC) have made new findings from the project ROSAS, dedicated to the study of free radicals - responsible, among other things, the aging celulary by extension-related diseases, such as hypertension, fibrosis, mitochondrial disease (included within the so-called rare diseases) or Alzheimer's. Research has been published in the journal Proceedings of the National Academy of
Science, Molecular and Cellular Biology and Molecular Cell.

Among other achievements, researchers have identified a biomarker that could serve as early warning of oxidative stress caused by free radicals and hence the risk of developing diseases such as hypertension or fibrosis. Specifically, scientists at the Centro de Investigaciones Biológicas CSIC in Madrid have identified a cellular enzyme, the GAPDH (glyceraldehyde 3-phosphate dehydrogenase), which in normal conditions, interacts with certain structural elements of the messenger RNA, resulting in a low production of endothelin -1, a peptide involved in regulating vascular tone and related diseases such as hypertension or fibrosis.

The first order approximation of the theory of the so-called simple material describes the viscoelastic behavior of soft polymers in large deformations with twelve time-dependent material functions and three material constants, all functions of the three invariants of the deformation tensor. Restricting consideration to deformations in which time shift invariance is preserved, a series of models was developed which describe the time dependence of the stress through the Boltzmann superposition integral incorporating into it a suitable nonlinear measure of strain. The theory was developed in its most general three-dimensional form. Its predictions for homogeneous deformations were tested in a series of experiments on an uncrosslinked styrene-butadiene copolymer.

For the prediction of the viscoelastic behavior of soft polymers the simplest form of the theory requires only one time function, the relaxation modulus. In addition, it requires a strain parameter which is a characteristic material constant. The dependence of this parameter on temperature and other material and experimental variables was examined on hand of estimates from published data as well as from the experimental results reported here.

The first order approximation of the theory of the so-called simple material describes the viscoelastic behavior of soft polymers in large deformations with twelve time-dependent material functions and three material constants, all functions of the three invariants of the deformation tensor. Restricting consideration to deformations in which time shift invariance is preserved, a series of models was developed which describe the time dependence of the stress through the Boltzmann superposition integral incorporating into it a suitable nonlinear measure of strain. The theory was developed in its most general three-dimensional form. Its predictions for homogeneous deformations were tested in a series of experiments on an uncrosslinked styrene-butadiene copolymer.

For the prediction of the viscoelastic behavior of soft polymers the simplest form of the theory requires only one time function, the relaxation modulus. In addition, it requires a strain parameter which is a characteristic material constant. The dependence of this parameter on temperature and other material and experimental variables was examined on hand of estimates from published data as well as from the experimental results reported here.

There was once an Eastern potentate, wise and enlightened, that she wanted to know everything about the people who inhabited the Earth. Called the king to his viziers and declared his will: - I direct that history is written all peoples and that it exposed how these people lived before and how the pass now, what it involved, what wars have been fought and where fight at the moment, what are the arts and crafts that thrive in different countries.

The king granted a period of five years in order to do his will. The viziers attended in silence and declining profound bows. Then gathered the most learned sages and transmitted them the will of the sovereign.

There was once an Eastern potentate, wise and enlightened, that she wanted to know everything about the people who inhabited the Earth. Called the king to his viziers and declared his will: - I direct that history is written all peoples and that it exposed how these people lived before and how the pass now, what it involved, what wars have been fought and where fight at the moment, what are the arts and crafts that thrive in different countries.

The king granted a period of five years in order to do his will. The viziers attended in silence and declining profound bows. Then gathered the most learned sages and transmitted them the will of the sovereign.