Chemical Engineering @ChemengFiles.Com

A study involving the Consejo Superior de Investigaciones Científicas (CSIC) the basis for the design of a vaccine to prevent the action of the parasites of the genus Ascaris, causing an infection of worms most common with a prevalence of around 25 percent of the world's population and particularly in children. Specifically, the research that is
published in PNAS, picking off one of the mechanisms that the parasite uses to resist the body's defenses infected.

The study, coordinated by researchers F. Xavier Gomis-Ruth, F. Xavier Avilés López and Joan Arolas, is a collaboration between groups of the Institute of Molecular Biology of Barcelona (CSIC) and Universidad Autónoma de Barcelona.

Mersana has announced positive results from preclinical studies for its second development candidate, XMT-1107. The studies showed that XMT-1107, a new analogue of fumagillin antiangiogenic conjugated FLEXIM (R) owned by Mersana showed a higher antitumor activity in xenograft tumor models in comparison with other antiangiogenic agents and extended exposure to the drug conjugate, supporting potential clinical utility of XMT-1107 as an anticancer agent.

"We are encouraged by the progress we are seeing today with XMT-1107, which addresses a new mechanism to inhibit proliferation of endothelial cells and has the potential to address a wide variety of angiogenic tumors, dijoJulie Olson, CEO of Mersana. "The first drugs in this class showed a promising activity in clinical practice but was interrupted due to the reversible neurological toxicity. The combination of our new" warhead "from fumagillin to FLEXIM using a specific link technology reduces exposure to the CNS in animal models for detection limits below. We hope moving XMT-1107 in clinical studies in early 2010. "

According to an article in Physics Today a team of researchers from Stanford University, UCLA and other 9 universities, laboratories and medical schools have collaborated in the creation of a microfluidic chip that demonstrates the possibility of a multistep organic synthesis on a single chip microfluidics.

The device produces 2-deoxy-2-[18F] fluoro-D-glucose (FDG), a radiopharmaceutical tracer used in positron emission tomography.