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New method for protecting non-acid stomach juice of carcinogenic acetaldehyde

Researchers at the University of Helsinki and Helsinki University Central Hospital, in cooperation with Biohit Oyj, have developed a new method that helps reduce the risk of cancer caused by acetaldehyde in a juice with no stomach acid . Have presented favorable results of early clinical trials in the 11 Finnish Gastroenterology Seminar (Gastropäivät XI).

The method uses a capsule that slowly releases small amounts of cysteine in the stomach so localized. The amino acid cysteine is a safe, secure and usually eat 1 or 2 grams a day as part of a standard diet. Granular free cysteine in the capsule (100-200 mg) is spreading slowly through the stomach, and even through it, effectively linking the molecules of acetaldehyde, leaving them inactive. Biohit aims to market its BioCyst capsules during the year 2009.

Helicobacter pylori infection or an autoimmune disease could produce an atrophic gastritis (damage to the gastric mucosa), then no stomach acid, which is the main risk factor for gastric cancer, increasing the risk of suffering from cancer esophagus. When the patient is healthy, a stomach with an acid gastric juice is free of bacteria, while bacteria in the mouth can live and multiply in a non-acid stomach.

Acetaldehyde is the first metabolic product of alcohol produced by microbes or sometimes by mucous cells. Acetaldehyde is also present in the smoke of snuff in quantities of about a thousand times superior to that of other carcinogens snuff. The combined risks of alcohol and snuff are synergistic.

Many soft drinks and foods contain small amounts of alcohol are transformed directly into acetaldehyde by microbes in the mouth and in a non-acid stomach. Stomachs in gastric juice with a little acid or acid-free, microbes also produce acetaldehyde and alcohol from sugar.

There are prominent evidence of recent studies showing that acetaldehyde is a carcinogen. The substance causes cancer in laboratory animals. There are three known human gene mutations that are known to increase the exposure of the upper digestive tract to acetaldehyde when consuming alcohol. People who carry these gene mutations have a much higher risk of developing cancer of the upper digestive tract if you drink alcohol, and there are hundreds of millions of people worldwide who have inherited these gene mutations. A person who smokes, is an alcohol-scale and carrying two of these genetic mutations are more likely to 380 risk of developing cancer of the esophagus.


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